104-105年度「國立臺灣大學與中央研究院創新性合作計畫」
以hTERT基因探討DNA甲基化與G-quadruplex之交互影響基因表現機制
卓越研究成果：
| 1. Wang Zi-Fu, Li Ming-Hao, Chen Wei-Wen, Hsu Shang-Te Danny, Chang Ta-Chau*, 2016, “A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes”, NUCLEIC ACIDS RESEARCH, 44(8), 3958-3968. |
| 2. Chen Wei-Wen, Yi Yung-Hsiang, Chien Cheng-Hao, Hsiung Kuei-Ching, Ma Tian-Hsiang, Lin Yi-Chun, Lo Szecheng J., Chang Ta-Chau*, 2016, “Specific polyunsaturated fatty acids modulate lipid delivery and oocyte development in C. elegans revealed by molecular-selective label-free imaging”, SCIENTIFIC REPORTS, 6(1), 32021-32033. |
| 3. TY Tseng, CC Chang, JJ Lin, TC Chang*, 2015, “A Fluorescent Anti-Cancer Agent, 3,6-bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide, Stains G-Quadruplexes in Cells and Inhibits Tumor Growth”, CURRENT TOPICS IN MEDICINAL CHEMISTRY, 15(19), 1964-1970.) |
| 4. MH Kuo, ZF Wang, TY Tseng, MH Li, ST Hsu, JJ Lin, TC Chang*, 2015, “Conformational Transition of a Hairpin Structure to G-Quadruplex within the WNT1 Gene Promoter”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(1), 210-218. |
| 5. WC Huang, TY Tseng, YT Chen, CC Chang, ZF Wang, CL Wang, TN Hsu, PT Li, CT Chen, JJ Lin, PJ Lou, TC Chang*, 2015, “Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents”, NUCLEIC ACIDS RESEARCH, 43(21), 10102-10113. |